Ipamorelin
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Synthetic peptide Ipamorelin, lyophilized reference standard for in vitro laboratory research.
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Price
$106.20
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Quantity
Out of stock
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Certificate of Analysis & Specifications
Documentation will be published once this lot completes third-party analytical release.
Released COA Library
Published Certificates of Analysis for Ipamorelin. All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
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Reports appear here once a batch has completed third-party analytical release.
Related research materials
Research Data
Chemical & Structural Identifiers
![2D chemical structure of (2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-phenylpropanoyl]amino]hexanamide](/structures/ipamorelin.svg)
- Chemical Name (IUPAC)
- (2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
- CAS Registry Number
- 170851-70-4
- PubChem CID
- 9831659
- Molecular Formula
- C38H49N9O5
- Molecular Weight
- 711.39 Da (711.86 g/mol average)
- Sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH2 (Single-letter: Aib-H-[D-2Nal]-[D-Phe]-K-NH2)
- SMILES
- CC(C)(C(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC3=CC=CC=C3C=C2)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCCN)C(=O)N)N
- InChIKey
- LZKODFWWVBTBNG-UHFFFAOYSA-N
- Salt / Counter-Ion
- Supplied as a lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- Ipamorelin, NNC 26-0161, Aib-His-D-2-Nal-D-Phe-Lys-NH2
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (RP-HPLC RT + UV vs. reference)
- Main peak retention time and UV spectrum conform to the reference standard.
- Physical Characterization
- Dense, white to off-white lyophilized solid cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Freely soluble in sterile laboratory-grade deionized water (≥ 20 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 15 mg/mL) for in vitro assay application.
- Enzymatic Stability & Handling: Incorporates α-aminoisobutyric acid (Aib) and D-amino acid stereoisomers (D-2-Nal, D-Phe), conferring elevated resistance to standard aminopeptidases; prepare concentrated working stocks freshly or aliquot into single-use fractions at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Synthetic pentapeptide growth hormone secretagogue (GHS) that functions as a selective agonist of the Growth Hormone Secretagogue Receptor type 1a (GHS-R1a / ghrelin receptor).
Cellular Pathways Investigated: Evaluated in primary anterior pituitary cell cultures and somatotroph models to monitor Gαq/11-protein coupling, phospholipase C (PLC) activation, downstream inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) turnover, and intracellular calcium mobilization ([Ca2+]i). In comparative cell culture assays, Ipamorelin selectively stimulates growth hormone transcription without inducing non-specific transcription or release of adrenocorticotropic hormone (ACTH), cortisol, prolactin, or aldosterone.
References (3)
- Raun, K., et al. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552–561.
- Jimenez-Reina, L., et al. (2002). In vitro effects of the growth hormone secretagogue ipamorelin on anterior pituitary cells. Life Sciences, 71(15), 1735–1744.
- Bowers, C. Y. (2001). Synergistic release of growth hormone by GHRH and GHRP/ghrelin receptor agonists in pituitary cell cultures. Journal of Pediatric Endocrinology & Metabolism, 14(S2), 587–598.
Technical Laboratory FAQs
What structural features characterize Ipamorelin?
Ipamorelin is a synthetic pentapeptide containing an unnatural N-terminal α-aminoisobutyric acid (Aib1), D-stereoisomers (D-2-Nal3, D-Phe4), and a C-terminal amide cap (Lys5-NH2), which protect the peptide from rapid enzymatic degradation by dipeptidyl peptidases in laboratory assay media.
Why is Ipamorelin characterized as a selective GHS-R1a agonist in vitro?
Unlike first- and second-generation secretagogues (such as GHRP-2 or GHRP-6), Ipamorelin binds the GHS-R1a receptor with high selectivity, triggering growth hormone-related calcium influx without provoking secondary signaling cascades for prolactin, ACTH, or cortisol in pituitary cell models.
What solvent conditions are recommended for preparing in vitro Ipamorelin working stocks?
Sterile deionized water or sterile PBS (pH 7.4) dissolves the lyophilized powder rapidly at concentrations ≥ 15 mg/mL, creating an isotonic carrier solution suitable for biochemical receptor binding and cell-based assays.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.