Cartalax
Lot #KRSCAR-20-261008-01From $44.95to $862.50
Cartalax peptide, lyophilized reference standard for in vitro laboratory research.
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Price
$44.96
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Quantity
In Stock · 19 Units Available
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Certificate of Analysis & Specifications
Documentation will be published once this lot completes third-party analytical release.
Released COA Library
Published Certificates of Analysis for Cartalax. All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
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Research Data
Chemical & Structural Identifiers
![2D chemical structure of (2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-carboxybutanoyl]amino]butanedioic acid (L-alanyl-L-$\alpha$-glutamyl-L-aspartic acid)](/structures/cartalax.svg)
- Chemical Name (IUPAC)
- (2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-carboxybutanoyl]amino]butanedioic acid (L-alanyl-L-α-glutamyl-L-aspartic acid)
- CAS Registry Number
- 205640-90-0 (also cited in chemical registries under 85806-95-7)
- PubChem CID
- 87815447
- ChEBI ID
- CHEBI:158137
- Molecular Formula
- C12H19N3O8
- Molecular Weight
- 333.12 Da (333.29 g/mol average)
- Sequence
- H-Ala-Glu-Asp-OH (AED)
- SMILES
- C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O)N
- InChIKey
- KXEVYGKATAMXJJ-ACZMJKKPSA-N
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH3COO-) salt or zwitterionic free peptide solid.
- Synonyms
- Cartalax, AED, T-31 Peptide, Alanyl-glutamyl-aspartic acid
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (RP-HPLC RT + UV vs. reference)
- Main peak retention time and UV spectrum conform to the reference standard.
- Physical Characterization
- Pure white to off-white lyophilized crystalline cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Highly hydrophilic; freely soluble in sterile laboratory-grade deionized water (≥ 20 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 15 mg/mL) for in vitro assay preparation.
- Handling & Aliquoting: The contiguous acidic amino acid side chains (glutamic acid and aspartic acid) impart high aqueous stability; prepare working stock solutions freshly or aliquot into single-use fractions at -20°C to avoid bacterial contamination and repeated freeze-thaw degradation cycles.
Mechanism & Literature
Structural Origin & Classification: Synthetic tripeptide (Ala-Glu-Asp) developed within the Khavinson short-peptide bioregulator framework at the St. Petersburg Institute of Bioregulation and Gerontology as a defined synthetic analogue of cartilage-derived peptide fractions.
Cellular Pathways Investigated: Studied across in vitro cell culture models—including primary chondrocytes, human diploid fibroblasts (WI-38, MRC-5), and mesenchymal stem cells (MSCs)—to evaluate epigenetic interactions, direct peptide-DNA binding constants, transcriptional modulation of extracellular matrix genes (such as collagen types I, II, and III), and regulation of matrix metalloproteinases (MMPs) versus tissue inhibitors of metalloproteinases (TIMPs).
References (3)
- Khavinson, V. K., et al. (2021). Peptide regulation of gene expression: a systematic review. Molecules, 26(22), 7053.
- Lin'kova, N. S., et al. (2016). Peptide regulation of skin fibroblast functions during their aging in vitro. Bulletin of Experimental Biology and Medicine, 161(1), 175–178.
- Ashapkin, V., et al. (2020). Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides. Molecular Biology Reports, 47(6), 4323–4329.
Technical Laboratory FAQs
What is the sequence and structural classification of Cartalax?
Cartalax is a synthetic linear tripeptide with the primary sequence Ala-Glu-Asp (AED), classified as a short peptide bioregulator corresponding to conserved sequence motifs in extracellular matrix biology.
How is Cartalax investigated in epigenetic and cell culture models?
Preclinical literature examines Cartalax for its ability to penetrate cellular membranes and interact with chromatin regulatory regions, modulating gene transcription associated with extracellular matrix synthesis and cellular senescence markers in cell lines.
What solvent conditions are recommended for in vitro Cartalax stock assays?
Sterile deionized water or sterile PBS (pH 7.4) dissolves the lyophilized powder rapidly at concentrations ≥ 15 mg/mL, providing a neutral delivery vehicle for cell-based assay modeling.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.