Cartalax
From $54.00to $847.50
For laboratory research use only. Not for human or animal use, consumption, diagnosis, treatment, or disease prevention.
This item is available only through approved account access.
Product Specifications
- Lot Number
- —
- Purity
- —
- Storage Temp
- 36°F to 46°F
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.
Documentation
Certificates of Analysis are supplied with each product lot where applicable.
Certificate of Analysis (COA)
Documentation will be available once product lots are received and tested.
All products currently listed on this site are for research purposes only.
COA Library
Published Certificates of Analysis for Cartalax. New deliveries are added as their batches are released.
No released COA for this strength yet
Reports appear here once a batch for this strength has been released.
Research Data
Chemical & Structural Identifiers
![2D chemical structure of (2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-carboxybutanoyl]amino]butanedioic acid (L-alanyl-L-$\alpha$-glutamyl-L-aspartic acid)](/structures/cartalax.svg)
- Chemical Name (IUPAC)
- (2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-carboxybutanoyl]amino]butanedioic acid (L-alanyl-L-α-glutamyl-L-aspartic acid)
- CAS Registry Number
- 205640-90-0 (also cited in chemical registries under 85806-95-7)
- PubChem CID
- 87815447
- ChEBI ID
- CHEBI:158137
- Molecular Formula
- C12H19N3O8
- Molecular Weight
- 333.12 Da (333.29 g/mol average)
- Sequence
- H-Ala-Glu-Asp-OH (AED)
- SMILES
- C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)O)N
- InChIKey
- KXEVYGKATAMXJJ-ACZMJKKPSA-N
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH3COO-) salt or zwitterionic free peptide solid.
- Synonyms
- Cartalax, AED, T-31 Peptide, Alanyl-glutamyl-aspartic acid
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (ESI-MS)
- Theoretical mass [M+H]+ = 334.1 Da; observed mass-to-charge ratio m/z = 334.1 ± 0.5 Da.
- Residual Moisture (Karl Fischer Titration)
- ≤ 1.5% water content.
- Endotoxin Screening (LAL Assay)
- < 1.0 EU/mg (Limulus Amebocyte Lysate per USP <85>).
- Sterility Validation
- USP <71> compliant (no microbial growth observed in nutrient broth cultures).
- Physical Characterization
- Pure white to off-white lyophilized crystalline cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Highly hydrophilic; freely soluble in sterile laboratory-grade deionized water (≥ 20 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 15 mg/mL) for in vitro assay preparation.
- Handling & Aliquoting: The contiguous acidic amino acid side chains (glutamic acid and aspartic acid) impart high aqueous stability; prepare working stock solutions freshly or aliquot into single-use fractions at -20°C to avoid bacterial contamination and repeated freeze-thaw degradation cycles.
Mechanism & Literature
Structural Origin & Classification: Synthetic tripeptide (Ala-Glu-Asp) developed within the Khavinson short-peptide bioregulator framework at the St. Petersburg Institute of Bioregulation and Gerontology as a defined synthetic analogue of cartilage-derived peptide fractions.
Cellular Pathways Investigated: Studied across in vitro cell culture models—including primary chondrocytes, human diploid fibroblasts (WI-38, MRC-5), and mesenchymal stem cells (MSCs)—to evaluate epigenetic interactions, direct peptide-DNA binding constants, transcriptional modulation of extracellular matrix genes (such as collagen types I, II, and III), and regulation of matrix metalloproteinases (MMPs) versus tissue inhibitors of metalloproteinases (TIMPs).
References (3)
- Khavinson, V. K., et al. (2021). Peptide regulation of gene expression: a systematic review. Molecules, 26(22), 7053.
- Lin'kova, N. S., et al. (2016). Peptide regulation of skin fibroblast functions during their aging in vitro. Bulletin of Experimental Biology and Medicine, 161(1), 175–178.
- Ashapkin, V., et al. (2020). Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides. Molecular Biology Reports, 47(6), 4323–4329.
Technical Laboratory FAQs
What is the sequence and structural classification of Cartalax?
Cartalax is a synthetic linear tripeptide with the primary sequence Ala-Glu-Asp (AED), classified as a short peptide bioregulator corresponding to conserved sequence motifs in extracellular matrix biology.
How is Cartalax investigated in epigenetic and cell culture models?
Preclinical literature examines Cartalax for its ability to penetrate cellular membranes and interact with chromatin regulatory regions, modulating gene transcription associated with extracellular matrix synthesis and cellular senescence markers in cell lines.
What solvent conditions are recommended for in vitro Cartalax stock assays?
Sterile deionized water or sterile PBS (pH 7.4) dissolves the lyophilized powder rapidly at concentrations ≥ 15 mg/mL, providing a neutral delivery vehicle for cell-based assay modeling.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.