CJC-1295 (NoDAC)
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CJC-1295 (modified GRF 1-29), lyophilized reference standard for in vitro laboratory research.
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$44.06
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Quantity
In Stock · 100 Units Available
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Certificate of Analysis & Specifications
Documentation will be published once this lot completes third-party analytical release.
Released COA Library
Published Certificates of Analysis for CJC-1295 (NoDAC). All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
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Research Data
Chemical & Structural Identifiers
- Chemical Name (IUPAC)
- Tetrasubstituted 29-amino acid growth hormone-releasing factor analog; [D-Ala2, Gln8, Ala15, Leu27]-GRF(1-29) amide.
- CAS Registry Number
- 863288-34-0
- PubChem CID
- 56841945
- Molecular Formula
- C152H252N44O42
- Molecular Weight
- 3365.89 Da (3367.95 g/mol average)
- Sequence
- Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
- SMILES
- CC[C@H](C)[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@H](Cc3ccc(O)cc3)N)[C@@H](C)O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)N
- InChIKey
- UWHJPGBKVNWUJJ-XLPDFYTHSA-N
- Salt / Counter-Ion
- Supplied as a lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- CJC-1295 (No DAC), Modified GRF 1-29, Mod GRF (1-29), Tetrasubstituted GRF(1-29)
- Registry Cross-Reference: PubChem CID 56841945 corresponds to the 29-residue unconjugated sequence and to the formula C152H252N44O42 given above. Registry records for this compound family apply the CJC-1295 name across both this form and the DAC-conjugated form, so confirm the batch against its Certificate of Analysis rather than the trade name alone.
- Variant Distinction: This entry describes the unconjugated 29-residue form, which terminates at Arg29 and carries no maleimide group. The DAC-conjugated analog is a separate catalog entry with a higher molecular mass; the two are not interchangeable in an assay.
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (RP-HPLC RT + UV vs. reference)
- Main peak retention time and UV spectrum conform to the reference standard.
- Physical Characterization
- Dense, white to off-white lyophilized solid cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Soluble in sterile laboratory-grade deionized water (≥ 10 mg/mL), sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 5 mg/mL), or dilute 0.1% sterile acetic acid for stock stabilization in in vitro assay applications.
- Solution Stability & Degradation Parameters: Lacks the C-terminal Drug Affinity Complex (DAC) bioconjugation moiety, resulting in shorter aqueous half-life profiles compared to DAC-conjugated analogs; aliquot into single-use laboratory fractions at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Structural Engineering Focus: Synthetic 29-amino acid peptide derived from the active amino-terminal core of growth hormone-releasing hormone (GHRH1--29). Engineered with four strategic amino acid substitutions—D-Ala2, Gln8, Ala15, and Leu27—specifically designed to resist rapid enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4) and oxidative degradation without including the covalent albumin-binding DAC linker.
Cellular Pathways Investigated: Evaluated in primary pituitary cell cultures and receptor-transfected cell lines (e.g., HEK293 expressing human GHRHR) to measure selective binding affinity (Ki) for the Growth Hormone-Releasing Hormone Receptor (GHRHR), stimulation of adenylyl cyclase, intracellular cyclic AMP (cAMP) accumulation, and downstream transcriptional activation of growth hormone (GH) expression.
References (3)
- Campbell, R. M., et al. (1997). Selective amino acid substitutions enhance the in vitro enzymatic stability and potency of human growth hormone-releasing factor(1-29) analogues. Journal of Peptide Research, 49(6), 527–537.
- Sackmann-Sala, L., et al. (2009). Activation of the GHRH receptor signaling pathway by synthetic GHRH analogs in vitro. Neuroendocrinology, 90(2), 109–118.
- Database record: National Center for Biotechnology Information. PubChem Compound Summary for CID 56841945. PubChem, U.S. National Library of Medicine. Registry cross-reference for CAS 863288-34-0, the unconjugated GRF(1-29) amide (record reviewed 2026-09-15).
Technical Laboratory FAQs
How does CJC-1295 (No DAC) differ from standard Sermorelin [GRF(1-29)]?
While Sermorelin matches native GHRH1--29, CJC-1295 (No DAC) incorporates four structural modifications (D-Ala2, Gln8, Ala15, Leu27), enhancing enzymatic resistance to DPP-4 cleavage in laboratory assay media.
What is the functional difference between CJC-1295 with DAC and without DAC?
CJC-1295 (No DAC) lacks the maleimidopropionic acid bioconjugation group, preventing covalent albumin coupling; this produces rapid receptor binding and clearance kinetics in in vitro cellular models rather than prolonged bioconjugation.
What vehicle is recommended for preparing in vitro CJC-1295 (No DAC) working stocks?
Sterile deionized water or sterile PBS (pH 7.4) provides rapid dissolution. For long-term stock stability in cell culture media preparation, a dilute 0.1% sterile acetic acid solution helps prevent deamidation of glutamine residues.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.