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Peptide ARA-290 (cibinetide), lyophilized reference standard for in vitro laboratory research.
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Price
$40.81
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Quantity
In Stock · 36 Units Available
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- Third-party HPLC tested. Every lot ships with a batch-linked certificate of analysis naming the laboratory, the method and the measured result. Browse certificates
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Certificate of Analysis & Specifications
HPLC Purity
99.98% HPLC
Area Normalization
Assay Content
10.01mg
Quantitative Target
Testing Lab
KMD Analytical
Lot Number
KRSARA-10-260827-01
Tested Sep 5, 2026
Storage
36°F to 46°F
Retest Date
Aug 27, 2028
Released COA Library
Published Certificates of Analysis for ARA-290. All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
10mg1 released lot
- View COA
Lot KRSARA-10-260827-01
Tested Sep 5, 2026 · KMD Analytical · HPLC 99.98% · Assay 10.01
Research Data
Chemical & Structural Identifiers
- Chemical Name (IUPAC)
- 5-Oxo-L-prolyl-L-glutamyl-L-glutaminyl-L-leucyl-L-glutamyl-L-arginyl-L-alanyl-L-leucyl-L-asparaginyl-L-seryl-L-serine
- CAS Registry Number
- 1208243-50-8
- PubChem CID
- 91810664
- Molecular Formula
- C51H84N16O21
- Molecular Weight
- 1257.3 g/mol (average, free peptide)
- Sequence
- pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH
- Physical Form
- Pure white to off-white lyophilized solid/powder.
- Synonyms
- ARA-290, Cibinetide, Helix B Surface Peptide (HBSP) Analog, Pyr-EPO(11-mer)
- Registry Cross-Reference: CAS 1208243-50-8 and PubChem CID 91810664 describe the free 11-residue peptide sequence shown above. The catalog material is supplied as a lyophilized salt; the counter-ion in the batch is stated on its Certificate of Analysis and is not fixed by the registry record.
- Identity Relationship to Erythropoietin: ARA-290 is a synthetic 11-amino acid sequence derived from the aqueous-exposed Helix B face of erythropoietin. It is a distinct molecular entity from erythropoietin and is not a truncated or modified form of the full-length glycoprotein.
Handling & Stability
Storage. Store dry lyophilized powder desiccated at -20°C to -80°C, sealed under an inert gas matrix and protected from light.
Solubility. Soluble in sterile laboratory-grade deionized water (≥ 10 mg/mL), sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 5 mg/mL), or dilute aqueous buffers for in vitro assay application.
- Solution Stability & Handling: The N-terminal pyroglutamate residue provides stability against standard aminopeptidase degradation; avoid excessive aeration, high-shear vortexing, and repeated freeze-thaw cycles once dissolved in aqueous buffers.
Mechanism & Literature
Structural Engineering Focus: Synthetic 11-amino acid linear peptide designed from the aqueous-exposed face of erythropoietin (EPO) Helix B. Engineered specifically to selectively engage the heteromeric Innate Repair Receptor (IRR)—a complex formed by the Erythropoietin Receptor subunit and the common β receptor (EPOR/CD131 heterodimer).
Cellular Pathways Investigated: Does not bind to the classical (EPOR)2 homodimer and exhibits zero erythropoietic activity in cell culture assays. Studied in neuronal, Schwann cell, and macrophage cell lines (e.g., RAW 264.7) to analyze downstream inhibition of nuclear factor-κB (NF-κB) nuclear translocation and phosphorylation of cytoprotective Akt/GSK-3β signaling cascades.
References (3)
- Brines, M., et al. (2008). Nonerythropoietic, tissue-protective peptides derived from the surface of erythropoietin B-helix. Proceedings of the National Academy of Sciences (PNAS), 105(31), 10925–10930.
- Swartjes, M., et al. (2014). ARA 290, a peptide derived from erythropoietin, activates the innate repair receptor and attenuates inflammatory signaling in vitro. Molecular Medicine, 20(1), 619–626.
- Database record: National Center for Biotechnology Information. PubChem Compound Summary for CID 91810664, Cibinetide. PubChem, U.S. National Library of Medicine. Registry cross-reference for CAS 1208243-50-8 (record reviewed 2026-09-15).
Technical Laboratory FAQs
How does ARA-290 differ functionally from full-length erythropoietin (EPO) in vitro?
ARA-290 selectively targets the heteromeric EPOR/CD131 Innate Repair Receptor (IRR) without binding the classical homodimeric (EPOR)2 receptor, completely uncoupling tissue-protective cellular signaling from erythropoiesis.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.