Quantity
Price
$88.00
Out of stock
Adamax
From $88.00to $660.00
For laboratory research use only. Not for human or animal use, consumption, diagnosis, treatment, or disease prevention.
This item is available only through approved account access.
Product Specifications
- Lot Number
- —
- Purity
- —
- Storage Temp
- 36°F to 46°F
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.
Documentation
Certificates of Analysis are supplied with each product lot where applicable.
Certificate of Analysis (COA)
Documentation will be available once product lots are received and tested.
All products currently listed on this site are for research purposes only.
COA Library
Published Certificates of Analysis for Adamax. New deliveries are added as their batches are released.
No released COA for this strength yet
Reports appear here once a batch for this strength has been released.
Research Data
Chemical & Structural Identifiers
- Chemical Name (IUPAC)
- N-Acetyl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolyl-glycyl-L-proline N-(adamantan-1-yl)amide
- CAS Registry Number
- Research Analog (Custom Peptide ID / Non-Assigned)
- Molecular Formula
- C49H68N10O10S
- Molecular Weight
- 988.48 g/mol (989.20 g/mol average)
- Sequence
- Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH-Adamantane (Ac-MEHFPGP-Adamantyl)
- SMILES
- CC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N3CCC[C@H]3C(=O)NCC(=O)N4CCC[C@H]4C(=O)NC56CC7CC(C5)CC(C7)C6
- Salt / Counter-Ion
- Supplied as a lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- Adamax, N-Acetyl-Semax-Adamantane, Ac-Semax-Adamantyl
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.0% area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (ESI-MS / MALDI-TOF)
- Theoretical mass [M+H]+ = 989.5 Da; observed mass-to-charge ratio m/z = 989.5 ± 0.5 Da.
- Residual Moisture (Karl Fischer Titration)
- ≤ 3.0% water content.
- Endotoxin Screening (LAL Assay)
- < 1.0 EU/mg (Limulus Amebocyte Lysate per USP <85>).
- Physical Form
- High-density, white to off-white lyophilized solid/cake.
Handling & Stability
Storage. Store lyophilized powder desiccated at -20°C to -80°C, strictly sealed under an inert gas matrix and protected from light.
Solubility. Soluble in sterile deionized water (≥ 10 mg/mL), sterile Phosphate-Buffered Saline (PBS, pH 7.4), or aqueous DMSO (10--20%) for in vitro assay stock delivery.
- Handling Warnings: Contains an oxidation-sensitive methionine residue and a lipophilic C-terminal adamantane cap; avoid vigorous vortexing, minimize aeration, and eliminate repeated freeze-thaw cycles once dissolved in aqueous buffers.
Mechanism & Literature
Structural Engineering Focus: Synthetic analog of the ACTH(4-10) fragment derivative Semax, modified with an N-terminal acetyl cap and a C-terminal (adamantan-1-yl) moiety. The hydrophobic adamantyl group was designed to evaluate enzymatic resistance against carboxypeptidase degradation in laboratory degradation assays.
Cellular Pathways: Investigated in in vitro neuronal and glial cell line models (such as PC12 and SH-SY5Y cultures) for the upregulation of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) mRNA expression, as well as downstream Tropomyosin receptor kinase B (TrkB) phosphorylation cascades.
References (2)
- Grivennikov, I. A., et al. (2008). Effects of Semax and its peptide derivatives on BDNF expression in glial and neuronal cell lines. Neurochemical Journal, 2(3), 195–201.
- Ashmarin, I. P., et al. (2005). Structure-activity relationship and neurotrophic signaling of ACTH(4-10) fragment derivatives in vitro. Molecular Biology, 39(2), 241–251.
Technical Laboratory FAQs
What structural modifications differentiate Adamax from Semax?
Adamax is modified from the core Met-Glu-His-Phe-Pro-Gly-Pro sequence with an N-terminal acetyl group (Ac-) and a C-terminal adamantane-1-amine group, providing higher lipophilicity and resistance to carboxypeptidases in cell assays.
Why is an adamantyl moiety conjugated to the C-terminus in research modeling?
The bulky, cage-like adamantane group serves as a hydrophobic anchor in structural biochemistry, evaluated in preclinical literature for its ability to increase metabolic stability against peptide-cleaving enzymes.
What solvent matrix is recommended for preparing in vitro Adamax assay solutions?
Sterile deionized water or PBS (pH 7.4) is suitable for standard dilutions. If higher stock concentrations are required, a co-solvent mixture of 10% sterile DMSO in laboratory-grade buffer enhances initial dissolution kinetics.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.