Adamax
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Adamax peptide (modified Semax analogue), lyophilized reference standard for in vitro laboratory research.
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Price
$49.46
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Quantity
In Stock · 100 Units Available
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Certificate of Analysis & Specifications
Documentation will be published once this lot completes third-party analytical release.
Released COA Library
Published Certificates of Analysis for Adamax. All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
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Reports appear here once a batch has completed third-party analytical release.
Research Data
Chemical & Structural Identifiers
- Chemical Name (IUPAC)
- N-Acetyl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolyl-glycyl-L-proline N-(adamantan-1-yl)amide
- Molecular Formula
- C49H68N10O10S
- Molecular Weight
- 988.48 g/mol (989.20 g/mol average)
- Sequence
- Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH-Adamantane (Ac-MEHFPGP-Adamantyl)
- SMILES
- CC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N3CCC[C@H]3C(=O)NCC(=O)N4CCC[C@H]4C(=O)NC56CC7CC(C5)CC(C7)C6
- Salt / Counter-Ion
- Supplied as a lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- Adamax, N-Acetyl-Semax-Adamantane, Ac-Semax-Adamantyl
- Registry Status: No CAS Registry Number is assigned to this catalog entry. "Adamax" is a catalog designation rather than a registry-standardized chemical name; the identifier set above follows the structure specification supplied for this material, not a registry authority record.
- Identity Basis: The formula, mass and SMILES above describe the N-acetylated MEHFPGP sequence bearing a C-terminal adamantane-1-amine cap as specified in the catalog record. Confirm the batch structure and counter-ion against the Certificate of Analysis before using these values in an assay.
- Literature Scope: The studies cited in Mechanism & Literature characterize the parent MEHFPGP sequence (Semax) and related ACTH(4-10) fragment derivatives. They were not performed on this specific catalog material, and no statement on this page should be read as a measured property of it.
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.0% area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (RP-HPLC RT + UV vs. reference)
- Main peak retention time and UV spectrum conform to the reference standard.
- Physical Form
- High-density, white to off-white lyophilized solid/cake.
Handling & Stability
Storage. Store lyophilized powder desiccated at -20°C to -80°C, strictly sealed under an inert gas matrix and protected from light.
Solubility. Soluble in sterile deionized water (≥ 10 mg/mL), sterile Phosphate-Buffered Saline (PBS, pH 7.4), or aqueous DMSO (10--20%) for in vitro assay stock delivery.
- Handling Warnings: Contains an oxidation-sensitive methionine residue and a lipophilic C-terminal adamantane cap; avoid vigorous vortexing, minimize aeration, and eliminate repeated freeze-thaw cycles once dissolved in aqueous buffers.
Mechanism & Literature
Structural Engineering Focus: Synthetic analog of the ACTH(4-10) fragment derivative Semax, modified with an N-terminal acetyl cap and a C-terminal (adamantan-1-yl) moiety. The hydrophobic adamantyl group was designed to evaluate enzymatic resistance against carboxypeptidase degradation in laboratory degradation assays.
Cellular Pathways: Investigated in in vitro neuronal and glial cell line models (such as PC12 and SH-SY5Y cultures) for the upregulation of Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) mRNA expression, as well as downstream Tropomyosin receptor kinase B (TrkB) phosphorylation cascades.
References (2)
- Grivennikov, I. A., et al. (2008). Effects of Semax and its peptide derivatives on BDNF expression in glial and neuronal cell lines. Neurochemical Journal, 2(3), 195–201.
- Ashmarin, I. P., et al. (2005). Structure-activity relationship and neurotrophic signaling of ACTH(4-10) fragment derivatives in vitro. Molecular Biology, 39(2), 241–251.
Technical Laboratory FAQs
What structural modifications differentiate Adamax from Semax?
Adamax is modified from the core Met-Glu-His-Phe-Pro-Gly-Pro sequence with an N-terminal acetyl group (Ac-) and a C-terminal adamantane-1-amine group, providing higher lipophilicity and resistance to carboxypeptidases in cell assays.
Why is an adamantyl moiety conjugated to the C-terminus in research modeling?
The bulky, cage-like adamantane group serves as a hydrophobic anchor in structural biochemistry, evaluated in preclinical literature for its ability to increase metabolic stability against peptide-cleaving enzymes.
What solvent matrix is recommended for preparing in vitro Adamax assay solutions?
Sterile deionized water or PBS (pH 7.4) is suitable for standard dilutions. If higher stock concentrations are required, a co-solvent mixture of 10% sterile DMSO in laboratory-grade buffer enhances initial dissolution kinetics.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.