GHRP-6
From $27.00to $225.00
Growth hormone releasing peptide GHRP-6, lyophilized reference standard for in vitro laboratory research.
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Price
$27.00
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Quantity
In Stock · 100 Units Available
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Certificate of Analysis & Specifications
Documentation will be published once this lot completes third-party analytical release.
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Published Certificates of Analysis for GHRP-6. All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
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Related research materials
Research Data
Chemical & Structural Identifiers
- Chemical Name (IUPAC)
- L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide
- CAS Registry Number
- 87616-84-0
- PubChem CID
- 9919153
- Molecular Formula
- C46H56N12O6
- Molecular Weight
- 872.44 Da (873.01 g/mol average)
- Sequence
- H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (Single-letter: H-[d-W]-A-W-[d-F]-K-NH2)
- SMILES
- C[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H](CC3=CC=CC=C3)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CC4=CNC5=CC=CC=C54)NC(=O)[C@@H](CC6=CNC=N6)N
- InChIKey
- VYPXZBSEUYGZOS-HBNGDCGZSA-N
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- GHRP-6, Growth Hormone Releasing Peptide-6, SKF-110679, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 280 nm (tryptophan indole chromophore detection).
- Identity Confirmation (RP-HPLC RT + UV vs. reference)
- Main peak retention time and UV spectrum conform to the reference standard.
- Physical Characterization
- Dense, white to off-white lyophilized solid cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct ambient light.
Solubility. Freely soluble in sterile laboratory-grade deionized water (≥ 20 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 15 mg/mL) for in vitro assay application.
- Photostability & Handling Parameters: Contains dual tryptophan residues (Trp2, Trp4) sensitive to photo-oxidation in aqueous environments; prepare concentrated working stocks under amber lighting conditions, avoid high-shear vortexing, and store single-use aliquots at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Synthetic first-generation hexapeptide growth hormone secretagogue (GHS) that functions as a selective agonist of the Growth Hormone Secretagogue Receptor type 1a (GHS-R1a / ghrelin receptor).
Cellular Pathways Investigated: Documented in in vitro anterior pituitary cell cultures and somatotroph assays to evaluate G-protein coupled (Gαq/11) signaling, activation of phospholipase C (PLC), generation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), mobilization of intracellular calcium ([Ca2+]i), and protein kinase C (PKC)-dependent stimulation of growth hormone transcription without displacing endogenous Growth Hormone-Releasing Hormone (GHRH).
References (3)
- Bowers, C. Y., et al. (1984). Structure-activity relationships of a synthetic pentapeptide that releases growth hormone in vitro. Endocrinology, 114(5), 1537–1545.
- Kojima, M., et al. (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402(6762), 656–660.
- Camanni, F., et al. (1998). Growth hormone-releasing peptides and their analogs: Mechanisms of action in vitro and preclinical models. Frontiers in Neuroendocrinology, 19(1), 47–72.
Technical Laboratory FAQs
What structural features characterize GHRP-6?
GHRP-6 is a synthetic hexapeptide containing unnatural D-amino acid stereoisomers (D-Trp2 and D-Phe5) and a C-terminal amide cap (Lys6-NH2), which confer resistance against standard laboratory carboxypeptidases and endopeptidases.
How does GHRP-6 transduce signals in pituitary cell models in vitro?
GHRP-6 binds the GHS-R1a receptor, activating the PLC/IP3 pathway to stimulate transient intracellular calcium ([Ca2+]i) influx, distinct from the adenylyl cyclase/cAMP cascade activated by GHRH receptor agonists.
What solvent conditions are recommended for preparing in vitro GHRP-6 stock solutions?
Sterile deionized water or sterile PBS (pH 7.4) provides rapid dissolution at concentrations exceeding 15 mg/mL, establishing a neutral carrier solution for cell culture and biochemical modeling.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.