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Mitochondrial-derived peptide MOTS-C, lyophilized reference standard for in vitro laboratory research.
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Price
$71.06
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Quantity
Out of stock
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- Third-party HPLC tested. Every lot ships with a batch-linked certificate of analysis naming the laboratory, the method and the measured result. Browse certificates
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Certificate of Analysis & Specifications
HPLC Purity
99.98% HPLC
Area Normalization
Assay Content
19.98mg
Quantitative Target
Testing Lab
KMD Analytical
Lot Number
KRSMOT-20-260904-01
Tested Sep 7, 2026
Storage
36°F to 46°F
Retest Date
Sep 4, 2028
Released COA Library
Published Certificates of Analysis for MOTS-C. All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
20mg1 released lot
- View COA
Lot KRSMOT-20-260904-01
Tested Sep 7, 2026 · KMD Analytical · HPLC 99.98% · Assay 19.98
Related research materials
Research Data
Chemical & Structural Identifiers
- Chemical Name (IUPAC)
- Mitochondrial Open Reading Frame of the 12S rRNA Type-c; 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome.
- CAS Registry Number
- 1627580-64-6
- PubChem CID
- 137700200
- Molecular Formula
- C101H152N28O22S2
- Molecular Weight
- 2173.10 Da (2174.62 g/mol average)
- Sequence
- MRWQEMGYIFYPRKLR
- SMILES
- CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc5c[nH]c6ccccc56)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)N
- InChIKey
- AQNZQZJSHGJWQO-ZEXUOBIOSA-N
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- MOTS-c, MOTSc Peptide, Mitochondrial-derived peptide MOTS-c.
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 280 nm (tyrosine and tryptophan chromophore detection).
- Identity Confirmation (RP-HPLC RT + UV vs. reference)
- Main peak retention time and UV spectrum conform to the reference standard.
- Physical Characterization
- Dense, white to off-white lyophilized solid cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Soluble in sterile laboratory-grade deionized water (≥ 10 mg/mL), sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 5 mg/mL), or dilute sterile 0.1% acetic acid for stock stabilization in in vitro assay applications.
- Handling & Methionine Oxidation Safeguards: Contains two methionine residues (Met1, Met6) and a tryptophan residue (Trp3) susceptible to oxidative degradation; avoid exposure to atmospheric oxygen and strong oxidants, prepare working solutions under inert nitrogen conditions when possible, and aliquot into single-use fractions at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Biochemical Origin & Genomic Architecture: Encoded within the mitochondrial 12S ribosomal RNA (MT-RNR1) gene locus as a short open reading frame (sORF). MOTS-c functions as an autonomous endocrine/paracrine signaling molecule bridging mitochondrial energy states with nuclear gene transcription.
Cellular Pathways Investigated: Evaluated across in vitro skeletal muscle myotubes (C2C12), primary hepatocytes, and adipocyte cell lines:
References (3)
- Lee, C., et al. (2015). The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces diet-induced obesity. Cell Metabolism, 21(3), 443–454.
- Kim, K. H., et al. (2018). The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metabolism, 28(3), 516–524.
- Reynolds, J. C., et al. (2021). MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical capacity and performance. Nature Communications, 12(1), 224.
Technical Laboratory FAQs
How is MOTS-c genetically encoded differently from standard nuclear-encoded peptides?
MOTS-c is a mitochondrial-derived peptide (MDP) translated from a short open reading frame located within the mitochondrial 12S rRNA gene, rather than from nuclear DNA transcription.
What is the biochemical mechanism of MOTS-c-induced AMPK activation in vitro?
MOTS-c disrupts folate metabolism and de novo purine biosynthesis, causing intracellular accumulation of the intermediate AICAR, which allosterically binds and promotes the phosphorylation of AMP-activated protein kinase (AMPK).
What solvent conditions are recommended for preparing in vitro MOTS-c stock assays?
Sterile deionized water or sterile PBS (pH 7.4) provides rapid dissolution at concentrations ≥ 5 mg/mL. Because MOTS-c contains multiple methionine residues, utilizing degassed buffers minimizes potential oxidation artifacts during downstream cell-based assays.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.