Quantity
Price
$36.00
100 available
This strength’s Certificate of Analysis isn’t published yet — add to cart will be enabled once the lab report is available.
5-Amino 1MQ
From $36.00to $270.00
For laboratory research use only. Not for human or animal use, consumption, diagnosis, treatment, or disease prevention.
This item is available only through approved account access.
Product Specifications
- Lot Number
- —
- Purity
- —
- Storage Temp
- 36°F to 46°F
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.
Documentation
Certificates of Analysis are supplied with each product lot where applicable.
Certificate of Analysis (COA)
Documentation will be available once product lots are received and tested.
All products currently listed on this site are for research purposes only.
COA Library — 50mg
Published Certificates of Analysis for 5-Amino 1MQ · 50mg. New deliveries are added as their batches are released.
No released COA for this strength yet
Reports appear here once a batch for this strength has been released.
Research Data
Chemical & Structural Identifiers
- Chemical Name (IUPAC)
- 5-Amino-1-methylquinolin-1-ium
- CAS Registry Number
- 42464-96-0
- PubChem CID
- 16218944
- Molecular Formula
- C10H11N2+ (cation) / C10H11IN2 (iodide salt) / C10H11ClN2 (chloride salt)
- Molecular Weight
- 159.09 g/mol (cation), 286.11 g/mol (as iodide salt)
- SMILES
- C[N+]1=CC=CC2=C(N)C=CC=C21
- InChIKey
- USNZYGDDWRZJRA-UHFFFAOYSA-M
- Salt / Counter-Ion
- Supplied as a stable crystalline iodide (I-) or chloride (Cl-) salt.
- Synonyms
- 5-Amino 1MQ, 5-amino-1-methylquinolinium
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization at UV λ = 254 nm and 214 nm.
- Identity Confirmation (ESI-MS)
- Theoretical mass [M]+ = 159.1 Da; observed [M]+ = 159.1 ± 0.5 Da.
- Residual Moisture (Karl Fischer)
- ≤ 1.5% water content.
- Endotoxin Screening (LAL Assay)
- < 1.0 EU/mg (Limulus Amebocyte Lysate per USP <85>).
- Physical Characterization
- Bright yellow to dark orange crystalline solid/powder.
Handling & Stability
Storage. Store dry powder desiccated at -20°C to -80°C, strictly protected from direct light.
Solubility. Soluble in anhydrous DMSO (≥ 25 mg/mL), sterile deionized water (≥ 10 mg/mL), and Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 5 mg/mL) for in vitro assay delivery.
- Photostability & Handling: Quinolinium derivatives exhibit photosensitivity in solution; prepare laboratory stock solutions under amber light or light-blocking conditions and avoid repeated freeze-thaw cycles.
Mechanism & Literature
Small-molecule, membrane-permeable selective inhibitor of Nicotinamide N-methyltransferase (NNMT), exhibiting an in vitro inhibitory constant (IC50) of ≈ 1.2 μM in cell-free enzymatic assays.
Cellular Pathways: Investigated in preclinical cell cultures (e.g., 3T3-L1 adipocytes and C2C12 myoblasts) to evaluate modulation of intracellular Nicotinamide Adenine Dinucleotide (NAD+) flux, reduction of 1-methylnicotinamide (1-MNA) production, and shifts in the S-adenosylmethionine to S-adenosylhomocysteine (SAM/SAH) methylation ratio.
References (2)
- Neelakantan, H., et al. (2018). Small molecule NNMT inhibitors for metabolic and cellular assay modeling. Biochemical Pharmacology, 147, 141–152.
- Gao, Y., et al. (2021). Nicotinamide N-methyltransferase targeting in skeletal muscle and cellular aging models. J. Med. Chem., 64(16), 11210–11237.
Technical Laboratory FAQs
What enzymatic target does 5-Amino 1MQ modulate in vitro?
5-Amino 1MQ functions as a competitive inhibitor of Nicotinamide N-methyltransferase (NNMT), blocking the methyl transfer from SAM to nicotinamide in cell-free assays.
Why is 5-Amino 1MQ formulated as a quinolinium salt?
The quaternary nitrogen in the quinolinium ring carries a positive ionic charge, requiring a counter-ion (such as iodide or chloride) to ensure crystalline stability and aqueous solubility for laboratory assay preparation.
What solvent is recommended for preparing in vitro 5-Amino 1MQ working solutions?
Anhydrous DMSO or sterile PBS (pH 7.4) is recommended for establishing initial concentrated stock solutions prior to dilution into cell culture media.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.