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Small molecule 5-amino-1-methylquinolinium iodide (5-Amino 1MQ), reference standard for in vitro laboratory research.
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Price
$38.49
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Quantity
In Stock · 29 Units Available
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Certificate of Analysis & Specifications
HPLC Purity
99.99% HPLC
Area Normalization
Assay Content
10.01mg
Quantitative Target
Testing Lab
KMD Analytical
Lot Number
KRSAMI-10-260827-01
Tested Sep 3, 2026
Storage
36°F to 46°F
Retest Date
Sep 1, 2028
Released COA Library
Published Certificates of Analysis for 5-Amino 1MQ. All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
Research Data
Classification note. This catalog entry is presented as a research compound, not a research peptide. The label is for product classification and search clarity; it is not a recommendation for use.
Chemical & Structural Identifiers
- Chemical Name (IUPAC)
- 5-Amino-1-methylquinolin-1-ium
- CAS Registry Number
- 42464-96-0
- PubChem CID
- 16218944
- Molecular Formula
- C10H11N2+ (cation) / C10H11IN2 (iodide salt) / C10H11ClN2 (chloride salt)
- Molecular Weight
- 159.09 g/mol (cation), 286.11 g/mol (as iodide salt)
- SMILES
- C[N+]1=CC=CC2=C(N)C=CC=C21
- InChIKey
- USNZYGDDWRZJRA-UHFFFAOYSA-M
- Salt / Counter-Ion
- Supplied as a stable crystalline iodide (I-) or chloride (Cl-) salt.
- Synonyms
- 5-Amino 1MQ, 5-amino-1-methylquinolinium
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization at UV λ = 254 nm and 214 nm.
- Identity Confirmation (RP-HPLC RT + UV vs. reference)
- Main peak retention time and UV spectrum conform to the reference standard.
- Physical Characterization
- Bright yellow to dark orange crystalline solid/powder.
Handling & Stability
Storage. Store dry powder desiccated at -20°C to -80°C, strictly protected from direct light.
Solubility. Soluble in anhydrous DMSO (≥ 25 mg/mL), sterile deionized water (≥ 10 mg/mL), and Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 5 mg/mL) for in vitro assay delivery.
- Photostability & Handling: Quinolinium derivatives exhibit photosensitivity in solution; prepare laboratory stock solutions under amber light or light-blocking conditions and avoid repeated freeze-thaw cycles.
Mechanism & Literature
Small-molecule, membrane-permeable selective inhibitor of Nicotinamide N-methyltransferase (NNMT), exhibiting an in vitro inhibitory constant (IC50) of ≈ 1.2 μM in cell-free enzymatic assays.
Cellular Pathways: Investigated in preclinical cell cultures (e.g., 3T3-L1 adipocytes and C2C12 myoblasts) to evaluate modulation of intracellular Nicotinamide Adenine Dinucleotide (NAD+) flux, reduction of 1-methylnicotinamide (1-MNA) production, and shifts in the S-adenosylmethionine to S-adenosylhomocysteine (SAM/SAH) methylation ratio.
References (2)
- Neelakantan, H., et al. (2018). Small molecule NNMT inhibitors for metabolic and cellular assay modeling. Biochemical Pharmacology, 147, 141–152.
- Gao, Y., et al. (2021). Nicotinamide N-methyltransferase targeting in skeletal muscle and cellular aging models. J. Med. Chem., 64(16), 11210–11237.
Technical Laboratory FAQs
What enzymatic target does 5-Amino 1MQ modulate in vitro?
5-Amino 1MQ functions as a competitive inhibitor of Nicotinamide N-methyltransferase (NNMT), blocking the methyl transfer from SAM to nicotinamide in cell-free assays.
Why is 5-Amino 1MQ formulated as a quinolinium salt?
The quaternary nitrogen in the quinolinium ring carries a positive ionic charge, requiring a counter-ion (such as iodide or chloride) to ensure crystalline stability and aqueous solubility for laboratory assay preparation.
What solvent is recommended for preparing in vitro 5-Amino 1MQ working solutions?
Anhydrous DMSO or sterile PBS (pH 7.4) is recommended for establishing initial concentrated stock solutions prior to dilution into cell culture media.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.