Quantity
Price
$46.00
100 available
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Vilon
From $46.00to $345.00
For laboratory research use only. Not for human or animal use, consumption, diagnosis, treatment, or disease prevention.
This item is available only through approved account access.
Product Specifications
- Lot Number
- —
- Purity
- —
- Storage Temp
- 36°F to 46°F
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.
Documentation
Certificates of Analysis are supplied with each product lot where applicable.
Certificate of Analysis (COA)
Documentation will be available once product lots are received and tested.
All products currently listed on this site are for research purposes only.
COA Library
Published Certificates of Analysis for Vilon. New deliveries are added as their batches are released.
No released COA for this strength yet
Reports appear here once a batch for this strength has been released.
Research Data
Chemical & Structural Identifiers
![2D chemical structure of (2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]pentanedioic acid (L-lysyl-L-glutamic acid)](/structures/vilon.svg)
- Chemical Name (IUPAC)
- (2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]pentanedioic acid (L-lysyl-L-glutamic acid)
- CAS Registry Number
- 45234-02-4
- PubChem CID
- 14304541
- Molecular Formula
- C11H21N3O5
- Molecular Weight
- 275.15 Da (275.30 g/mol average)
- Sequence
- H-Lys-Glu-OH (Single-letter: KE)
- SMILES
- C(CCN)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)N
- InChIKey
- UJZMWTNGUUXRSC-UHFFFAOYSA-N
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- Vilon, KE Dipeptide, Dipeptide KE, Lys-Glu, H-Lys-Glu-OH, Synthetic Thymus Bioregulator Dipeptide
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (ESI-MS / MALDI-TOF)
- Theoretical mass [M+H]+ = 276.2 Da; observed mass-to-charge ratio m/z = 276.2 ± 0.3 Da.
- Residual Moisture (Karl Fischer Titration)
- ≤ 2.0% water content.
- Endotoxin Screening (LAL Assay)
- < 1.0 EU/mg (Limulus Amebocyte Lysate per USP <85>).
- Sterility Validation
- USP <71> compliant (no observed microbial proliferation in fluid thioglycollate or soybean-casein digest broths).
- Physical Characterization
- Dense, white to off-white lyophilized crystalline cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Highly hydrophilic zwitterionic structure; freely soluble in sterile laboratory-grade deionized water (≥ 30 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 25 mg/mL) for in vitro assay application.
- Aliquoting & Chemical Stability: Lacks oxidation-prone residues (no sulfur-containing or aromatic side chains), providing chemical resilience in neutral aqueous solutions; prepare concentrated working stocks freshly or aliquot into single-use fractions at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Structural Origin & Classification: Synthetic short-chain dipeptide bioregulator (Lys-Glu) developed within the Khavinson peptide platform as a synthetic peptide analogue of thymic tissue extracts (Thymalin).
Cellular Pathways Investigated: Evaluated across in vitro primary thymocytes, peripheral blood lymphocytes, monocytes (THP-1), and splenic cultures to analyze:
References (3)
- Khavinson, V. K., et al. (2003). Epigenetic aspects of peptidergic regulation of cellular functions. Bulletin of Experimental Biology and Medicine, 136(3), 288–292.
- Lezhava, T. A., et al. (2011). Bioregulator Vilon-induced deheterochromatinization in human lymphocyte cultures. Biogerontology, 12(3), 197–206.
- Khavinson, V. K., et al. (2014). Peptide regulation of gene expression and protein synthesis in cell-free and cellular models. Bulletin of Experimental Biology and Medicine, 157(1), 142–146.
Technical Laboratory FAQs
What is the sequence and structural classification of Vilon?
Vilon is a synthetic linear dipeptide composed of L-lysine and L-glutamic acid (Lys-Glu, KE) with a molecular weight of 275.30 g/mol, categorized as an ultrashort peptide bioregulator.
How does Vilon exert epigenetic effects in cellular research models?
Due to its low molecular weight, Vilon crosses cellular and nuclear membranes without classical cell-surface receptor binding, interacting directly with nucleosomal DNA and histones to stimulate chromatin unraveling (deheterochromatinization) and reactivate suppressed gene transcription.
What solvent conditions are recommended for preparing in vitro Vilon stock solutions?
Sterile deionized water or sterile PBS (pH 7.4) provides rapid dissolution at concentrations exceeding 25 mg/mL, establishing a neutral carrier matrix for cell viability assays, chromatin analysis, and cytokine profiling.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.