Vilon
From $43.20to $360.00
Vilon dipeptide (Lys-Glu), lyophilized reference standard for in vitro laboratory research.
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Price
$43.20
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Quantity
In Stock · 100 Units Available
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Certificate of Analysis & Specifications
Documentation will be published once this lot completes third-party analytical release.
Released COA Library
Published Certificates of Analysis for Vilon. All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
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Research Data
Chemical & Structural Identifiers
![2D chemical structure of (2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]pentanedioic acid (L-lysyl-L-glutamic acid)](/structures/vilon.svg)
- Chemical Name (IUPAC)
- (2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]pentanedioic acid (L-lysyl-L-glutamic acid)
- CAS Registry Number
- 45234-02-4
- PubChem CID
- 14304541
- Molecular Formula
- C11H21N3O5
- Molecular Weight
- 275.15 Da (275.30 g/mol average)
- Sequence
- H-Lys-Glu-OH (Single-letter: KE)
- SMILES
- C(CCN)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)O)N
- InChIKey
- UJZMWTNGUUXRSC-UHFFFAOYSA-N
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- Vilon, KE Dipeptide, Dipeptide KE, Lys-Glu, H-Lys-Glu-OH, Synthetic Thymus Bioregulator Dipeptide
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (RP-HPLC RT + UV vs. reference)
- Main peak retention time and UV spectrum conform to the reference standard.
- Physical Characterization
- Dense, white to off-white lyophilized crystalline cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Highly hydrophilic zwitterionic structure; freely soluble in sterile laboratory-grade deionized water (≥ 30 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 25 mg/mL) for in vitro assay application.
- Aliquoting & Chemical Stability: Lacks oxidation-prone residues (no sulfur-containing or aromatic side chains), providing chemical resilience in neutral aqueous solutions; prepare concentrated working stocks freshly or aliquot into single-use fractions at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Structural Origin & Classification: Synthetic short-chain dipeptide bioregulator (Lys-Glu) developed within the Khavinson peptide platform as a synthetic peptide analogue of thymic tissue extracts (Thymalin).
Cellular Pathways Investigated: Evaluated across in vitro primary thymocytes, peripheral blood lymphocytes, monocytes (THP-1), and splenic cultures to analyze:
References (3)
- Khavinson, V. K., et al. (2003). Epigenetic aspects of peptidergic regulation of cellular functions. Bulletin of Experimental Biology and Medicine, 136(3), 288–292.
- Lezhava, T. A., et al. (2011). Bioregulator Vilon-induced deheterochromatinization in human lymphocyte cultures. Biogerontology, 12(3), 197–206.
- Khavinson, V. K., et al. (2014). Peptide regulation of gene expression and protein synthesis in cell-free and cellular models. Bulletin of Experimental Biology and Medicine, 157(1), 142–146.
Technical Laboratory FAQs
What is the sequence and structural classification of Vilon?
Vilon is a synthetic linear dipeptide composed of L-lysine and L-glutamic acid (Lys-Glu, KE) with a molecular weight of 275.30 g/mol, categorized as an ultrashort peptide bioregulator.
How does Vilon exert epigenetic effects in cellular research models?
Due to its low molecular weight, Vilon crosses cellular and nuclear membranes without classical cell-surface receptor binding, interacting directly with nucleosomal DNA and histones to stimulate chromatin unraveling (deheterochromatinization) and reactivate suppressed gene transcription.
What solvent conditions are recommended for preparing in vitro Vilon stock solutions?
Sterile deionized water or sterile PBS (pH 7.4) provides rapid dissolution at concentrations exceeding 25 mg/mL, establishing a neutral carrier matrix for cell viability assays, chromatin analysis, and cytokine profiling.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.