Thymagen
From $49.50to $412.50
Thymagen peptide, lyophilized reference standard for in vitro laboratory research.
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Price
$49.50
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Quantity
In Stock · 100 Units Available
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Certificate of Analysis & Specifications
Documentation will be published once this lot completes third-party analytical release.
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Research Data
Chemical & Structural Identifiers
![2D chemical structure of (2S)-2-[[(2S)-2-amino-4-carboxybutanoyl]amino]-3-(1H-indol-3-yl)propanoic acid (L-$\alpha$-glutamyl-L-tryptophan)](/structures/thymagen.svg)
- Chemical Name (IUPAC)
- (2S)-2-[[(2S)-2-amino-4-carboxybutanoyl]amino]-3-(1H-indol-3-yl)propanoic acid (L-α-glutamyl-L-tryptophan)
- CAS Registry Number
- 115918-05-9 (Free acid / base); 122933-59-9 (Monosodium salt)
- PubChem CID
- 9832410
- Molecular Formula
- C16H19N3O5
- Molecular Weight
- 333.13 Da (333.34 g/mol average; monosodium salt: 355.32 g/mol)
- Sequence
- H-Glu-Trp-OH (Single-letter: EW)
- SMILES
- C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)O)NC(=O)[C@H](CCC(=O)O)N
- InChIKey
- RBLJOHWVRVGXRM-UHFFFAOYSA-N
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH3COO-), monosodium (Na+), or trifluoroacetate (CF3COO-) salt.
- Synonyms
- Thymagen, Thymogen, Timogen, Dipeptide EW, Glu-Trp, Thymus Bioregulator Dipeptide
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 280 nm (tryptophan indole chromophore detection).
- Identity Confirmation (RP-HPLC RT + UV vs. reference)
- Main peak retention time and UV spectrum conform to the reference standard.
- Physical Characterization
- Dense, white to off-white lyophilized crystalline cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Highly hydrophilic; freely soluble in sterile laboratory-grade deionized water (≥ 25 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 20 mg/mL) for in vitro assay application.
- Tryptophan Photostability & Oxidation Controls: Contains an indole-bearing tryptophan residue (Trp2) susceptible to photo-oxidation and auto-oxidation; prepare working solutions using degassed buffers under subdued or amber lighting, avoid vigorous high-shear vortexing, and store single-use aliquots at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Structural Origin & Classification: Synthetic short-chain dipeptide bioregulator (Glu-Trp) acting as a synthetic thymomimetic. Derived from thymic polypeptide extract fractions (Thymalin) to evaluate targeted immunoregulatory and epigenetic signaling cascades without complex native protein mixtures.
Cellular Pathways Investigated: Evaluated across primary thymocyte cultures, peripheral blood mononuclear cells (PBMCs), and bone marrow precursor cell lines to quantify:
References (3)
- Morozov, V. G., & Khavinson, V. K. (1997). Natural and synthetic thymic peptides. International Journal of Immunopharmacology, 19(9-10), 501–505.
- Khavinson, V. K., et al. (2014). Peptide regulation of gene expression and protein synthesis in cell-free and cellular models. Bulletin of Experimental Biology and Medicine, 157(1), 142–146.
- Kozlov, V. A., et al. (2007). Effect of the dipeptide Glu-Trp (Thymogen) on immune response and T-cell differentiation in vitro. Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii, (2), 48–52.
Technical Laboratory FAQs
What is the chemical composition and origin of Thymagen (Thymogen)?
Thymagen is a synthetic linear dipeptide composed of L-glutamic acid and L-tryptophan (Glu-Trp, EW) with a molecular weight of 333.34 g/mol, engineered as the minimal active synthetic analogue of natural thymic peptide fractions.
How does Thymagen modulate T-cell receptor expression in vitro?
In cell culture models, Thymagen penetrates lymphoid cell membranes and associates with nuclear chromatin, stimulating the transcriptional upregulation and cell-surface presentation of T-cell maturation markers including CD3, CD4, and CD8.
What solvent conditions are recommended for preparing in vitro Thymagen stock solutions?
Sterile deionized water or sterile PBS (pH 7.4) dissolves Thymagen rapidly at concentrations ≥ 20 mg/mL. Preparing working stocks with degassed aqueous buffers under light-protected conditions prevents oxidation of the Trp2 indole core.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.