Pinealon
From $32.00to $465.00
For laboratory research use only. Not for human or animal use, consumption, diagnosis, treatment, or disease prevention.
This item is available only through approved account access.
Product Specifications
- Lot Number
- —
- Purity
- —
- Storage Temp
- 36°F to 46°F
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.
Documentation
Certificates of Analysis are supplied with each product lot where applicable.
Certificate of Analysis (COA)
Documentation will be available once product lots are received and tested.
All products currently listed on this site are for research purposes only.
COA Library
Published Certificates of Analysis for Pinealon. New deliveries are added as their batches are released.
No released COA for this strength yet
Reports appear here once a batch for this strength has been released.
Research Data
Chemical & Structural Identifiers
- Chemical Name (IUPAC)
- L-α-glutamyl-L-α-aspartyl-L-arginine
- CAS Registry Number
- 175175-23-2
- Molecular Formula
- C₁₅H₂₆N₆O₈
- Molecular Weight
- 418.41 g/mol (average)
- Sequence
- H-Glu-Asp-Arg-OH (single-letter: EDR)
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH₃COO⁻) or trifluoroacetate (CF₃COO⁻) salt.
- Synonyms
- Pinealon, Pinealon tripeptide, EDR peptide, Glu-Asp-Arg
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.0% area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (ESI-MS / MALDI-TOF)
- Theoretical mass [M+H]⁺ = 419.2 Da; observed mass-to-charge ratio m/z = 419.2 ± 0.5 Da.
- Residual Moisture (Karl Fischer Titration)
- ≤ 2.0% water content.
- Endotoxin Screening (LAL Assay)
- < 1.0 EU/mg (Limulus Amebocyte Lysate per USP <85>).
- Sterility Validation
- USP <71> compliant (no observed microbial proliferation).
- Physical Characterization
- Dense, white to off-white lyophilized solid cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at −20°C to −80°C, protected from atmospheric moisture and direct light.
Solubility. Freely soluble in sterile laboratory-grade deionized water (≥ 10 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 10 mg/mL) for in vitro assay application.
- Handling & Aliquoting: Exhibits good aqueous stability; prepare concentrated stock solutions freshly or aliquot into single-use fractions at −20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Structural Origin & Classification: Synthetic tripeptide (Glu-Asp-Arg, EDR) developed within the short peptide bioregulator framework, in which short synthetic sequences are investigated for their influence on gene transcription and cellular homeostasis.
Cellular Pathways Investigated: Documented in in vitro and preclinical models for modulation of neuronal cell viability under oxidative stress, regulation of antioxidant enzyme systems (superoxide dismutase and catalase activity), and influence on neurotrophic signaling markers in cultured neuronal and glial cell models.
Technical Laboratory FAQs
What is the sequence and structural classification of Pinealon?
Pinealon is a synthetic linear tripeptide with the primary sequence Glu-Asp-Arg (EDR) and an average molecular mass of 418.41 g/mol, categorized as a short-chain peptide bioregulator.
How is Pinealon characterized in oxidative-stress and neuronal models in vitro?
Preclinical literature examines Pinealon for its capacity to modulate antioxidant enzyme activity and neuronal survival markers in cultured neuronal and glial models subjected to oxidative challenge.
What solvent matrix is recommended for preparing in vitro Pinealon stock solutions?
Sterile deionized water or sterile PBS (pH 7.4) provides immediate dissolution at concentrations of 10 mg/mL or greater, forming a neutral carrier for cell culture and biochemical assays.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.