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Tripeptide KPV (Lys-Pro-Val, α-MSH 11-13), lyophilized reference standard for in vitro laboratory research.
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Price
$33.26
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Quantity
In Stock · 23 Units Available
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Certificate of Analysis & Specifications
HPLC Purity
98.49% HPLC
Area Normalization
Assay Content
10.43mg
Quantitative Target
Testing Lab
KMD Analytical
Lot Number
KRSKPV-10-260908-01
Tested Sep 22, 2026
Storage
36°F to 46°F
Retest Date
Sep 18, 2028
Released COA Library
Published Certificates of Analysis for KPV. All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
10mg1 released lot
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Lot KRSKPV-10-260908-01
Tested Sep 22, 2026 · KMD Analytical · HPLC 98.49% · Assay 10.43
Research Data
Chemical & Structural Identifiers
![2D chemical structure of (2S)-1-[(2S)-2,6-diaminohexanoyl]-N-[(2S)-1-hydroxy-3-methylbutan-2-yl]pyrrolidine-2-carboxamide (L-lysyl-L-prolyl-L-valine)](/structures/kpv.svg)
- Chemical Name (IUPAC)
- (2S)-1-[(2S)-2,6-diaminohexanoyl]-N-[(2S)-1-hydroxy-3-methylbutan-2-yl]pyrrolidine-2-carboxamide (L-lysyl-L-prolyl-L-valine)
- CAS Registry Number
- 67727-97-3
- PubChem CID
- 125564
- Molecular Formula
- C16H31N5O4
- Molecular Weight
- 357.24 Da (357.45 g/mol average)
- Sequence
- H-Lys-Pro-Val-OH (Single-letter: KPV)
- SMILES
- CC(C)[C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N
- InChIKey
- ODHQKDOEXFUXNQ-YWTDRTNVSA-N
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- KPV, KPV Tripeptide, α-MSH(11--13), Lys-Pro-Val, ACTH(11-13)
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (RP-HPLC RT + UV vs. reference)
- Main peak retention time and UV spectrum conform to the reference standard.
- Physical Characterization
- Dense, white to off-white lyophilized crystalline powder/cake.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Highly hydrophilic; freely soluble in sterile laboratory-grade deionized water (≥ 25 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 20 mg/mL) for in vitro assay application.
- Membrane Transporter Specificity & Handling: Exhibits high aqueous stability; transported across cellular membranes via the oligopeptide transporter PepT1 (SLC15A1); prepare concentrated working stocks freshly or aliquot into single-use fractions at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Biochemical Target & Classification: Synthetic linear tripeptide corresponding to the carboxy-terminal residues 11–13 of α-melanocyte-stimulating hormone (α-MSH). Exhibits zero melanotropic pigmentation activity (does not bind MC1R to stimulate melanogenesis) while retaining specific non-pigmentary cellular signaling pathways.
Cellular Pathways Investigated: Extensively documented in in vitro intestinal epithelial cell models (Caco-2, HT-29) and macrophage cultures (RAW 264.7) to evaluate PepT1-mediated cellular uptake, cytoplasmic interaction with downstream signaling proteins, inhibition of Nuclear Factor-κB (NF-κB) p65 nuclear translocation, suppression of IκBα phosphorylation, and downregulation of proinflammatory cytokine gene transcription (TNF-α, IL-1β, IL-6, IL-8).
References (3)
- Luger, T. A., et al. (2003). The C-terminal tripeptide of alpha-MSH (KPV) inhibits NF-kappaB activation in vitro. Annals of the New York Academy of Sciences, 994(1), 133–140.
- Dalmasso, G., et al. (2008). PepT1-mediated transport of the tripeptide KPV modulates cellular inflammatory signaling in intestinal epithelial cells in vitro. Gastroenterology, 134(1), 166–178.
- Land, S. C. (2012). Cellular mechanism of alpha-MSH and its C-terminal tripeptide KPV in cell culture and oxidative stress models. Peptides, 34(2), 405–412.
Technical Laboratory FAQs
What is the sequence and origin of the KPV tripeptide?
KPV is a synthetic tripeptide with the sequence Lys-Pro-Val, derived from the C-terminal sequence of α-melanocyte-stimulating hormone (α-MSH11--13), possessing selective signaling properties without inducing melanocortin-1 receptor (MC1R) melanogenic activation.
How does KPV cross cellular membranes in epithelial cell culture assays?
KPV is actively transported across epithelial cell membranes via the proton-coupled oligopeptide transporter 1 (PepT1 / SLC15A1), facilitating rapid intracellular accumulation in cell-based assays.
What solvent conditions are recommended for preparing in vitro KPV stock solutions?
Sterile deionized water or sterile PBS (pH 7.4) dissolves KPV rapidly at concentrations ≥ 20 mg/mL, creating a neutral delivery carrier suitable for cell culture and biochemical receptor assays.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.