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Tetrapeptide Epitalon, lyophilized reference standard for in vitro laboratory research.
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Price
$29.66
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Quantity
In Stock · 39 Units Available
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- Third-party HPLC tested. Every lot ships with a batch-linked certificate of analysis naming the laboratory, the method and the measured result. Browse certificates
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Certificate of Analysis & Specifications
HPLC Purity
99.98% HPLC
Area Normalization
Assay Content
10.13mg
Quantitative Target
Testing Lab
KMD Analytical
Lot Number
KRSEPI-10-260908-01
Tested Sep 21, 2026
Storage
36°F to 46°F
Retest Date
Sep 18, 2028
Released COA Library
Published Certificates of Analysis for Epitalon. All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
10mg1 released lot
- View COA
Lot KRSEPI-10-260908-01
Tested Sep 21, 2026 · KMD Analytical · HPLC 99.98% · Assay 10.13
Research Data
Chemical & Structural Identifiers
![2D chemical structure of L-alanyl-L-$\alpha$-glutamyl-L-$\alpha$-aspartylglycine ((2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-carboxybutanoyl]amino]-3-(carboxymethylcarbamoyl)propanoic acid)](/structures/epitalon.svg)
- Chemical Name (IUPAC)
- L-alanyl-L-α-glutamyl-L-α-aspartylglycine ((2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-carboxybutanoyl]amino]-3-(carboxymethylcarbamoyl)propanoic acid)
- CAS Registry Number
- 307297-39-8
- PubChem CID
- 219042
- Molecular Formula
- C14H22N4O9
- Molecular Weight
- 390.14 Da (390.35 g/mol average)
- Sequence
- H-Ala-Glu-Asp-Gly-OH (Single-letter: AEDG)
- SMILES
- C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O)N
- InChIKey
- OZXFPFPNLGIUFS-IMRODAPBSA-N
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- Epitalon, Epithalon, Epithalone, AEDG Peptide, Ala-Glu-Asp-Gly, Pineal Bioregulator Synthetic Analog
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (RP-HPLC RT + UV vs. reference)
- Main peak retention time and UV spectrum conform to the reference standard.
- Physical Characterization
- Dense, white to off-white lyophilized solid cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Highly hydrophilic; freely soluble in sterile laboratory-grade deionized water (≥ 20 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 15 mg/mL) for in vitro assay application.
- Handling & Aliquoting: Exhibits high aqueous chemical stability; prepare concentrated stock solutions freshly or aliquot into single-use fractions at -20°C to eliminate hydrolytic degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Structural Origin & Classification: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed as a defined sequence analogue of epithalamin, a natural pineal polypeptide complex investigated within the short peptide bioregulator framework.
Cellular Pathways Investigated: Documented in in vitro somatic cell models—such as human diploid fibroblasts (WI-38, MRC-5) and retinal pigment epithelial cells—to assess direct peptide-DNA binding interactions, transcriptional induction of the human telomerase reverse transcriptase catalytic subunit (hTERT), enzymatic activity via Telomeric Repeat Amplification Protocol (TRAP) assays, chromatin decondensation (deheterochromatinization), and modulation of senescence-associated β-galactosidase (SA-β-gal) expression.
References (3)
- Khavinson, V. K., et al. (2003). Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells in vitro. Bulletin of Experimental Biology and Medicine, 135(6), 590–592.
- Khavinson, V. K., et al. (2020). Peptide regulation of gene expression and protein synthesis in cellular aging models. Current Pharmaceutical Design, 26(32), 3959–3971.
- Anisimov, V. N., et al. (2001). Dose-dependent effects of Epithalon on biomarker transcription in cell-free and in vitro systems. Neuro Endocrinology Letters, 22(6), 441–448.
Technical Laboratory FAQs
What is the sequence and structural classification of Epitalon?
Epitalon is a synthetic linear tetrapeptide with the primary sequence Ala-Glu-Asp-Gly (AEDG) and a monoisotopic molecular mass of 390.14 Da, categorized as a short-chain peptide bioregulator.
How is Epitalon evaluated in telomerase and epigenetic assays in vitro?
Preclinical literature examines Epitalon for its capacity to cross cellular membranes, interact with site-specific DNA promoter sequences, and stimulate hTERT gene expression in cultured somatic cells.
What solvent matrix is recommended for preparing in vitro Epitalon stock assays?
Sterile deionized water or sterile PBS (pH 7.4) provides immediate dissolution at concentrations exceeding 15 mg/mL, creating a neutral delivery carrier for cell culture and biochemical modeling.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.