Quantity
Price
$25.00
Out of stock
Selank
From $25.00to $900.00
For laboratory research use only. Not for human or animal use, consumption, diagnosis, treatment, or disease prevention.
This item is available only through approved account access.
Product Specifications
- Lot Number
- —
- Purity
- —
- Storage Temp
- 36°F to 46°F
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.
Documentation
Certificates of Analysis are supplied with each product lot where applicable.
Certificate of Analysis (COA)
Documentation will be available once product lots are received and tested.
All products currently listed on this site are for research purposes only.
COA Library
Published Certificates of Analysis for Selank. New deliveries are added as their batches are released.
No released COA for this strength yet
Reports appear here once a batch for this strength has been released.
Research Data
Chemical & Structural Identifiers
![2D chemical structure of L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolyl-glycyl-L-proline ((2S)-1-[2-[[(2S)-1-[(2S)-5-guanidino-2-[[(2S)-1-[(2S)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid)](/structures/selank.svg)
- Chemical Name (IUPAC)
- L-threonyl-L-lysyl-L-prolyl-L-arginyl-L-prolyl-glycyl-L-proline ((2S)-1-[2-[[(2S)-1-[(2S)-5-guanidino-2-[[(2S)-1-[(2S)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid)
- CAS Registry Number
- 129954-34-3
- PubChem CID
- 11765600
- Molecular Formula
- C33H57N11O9
- Molecular Weight
- 751.43 Da (751.88 g/mol average)
- Sequence
- H-Thr-Lys-Pro-Arg-Pro-Gly-Pro-OH (Single-letter: TKPRPGP)
- SMILES
- CC(C(C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)N2CCCC2C(=O)NCC(=O)N3CCCC3C(=O)O)N)O
- InChIKey
- YVJYHJVTVYHYQG-UHFFFAOYSA-N
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- Selank, TP-7, Tuftsin Analog TP-7, Thr-Lys-Pro-Arg-Pro-Gly-Pro, Heptapeptide Selank
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (ESI-MS / MALDI-TOF)
- Theoretical mass [M+H]+ = 752.5 Da; observed mass-to-charge ratio m/z = 752.5 ± 0.4 Da (with confirmed divalent ion [M+2H]2+ = 376.8 Da).
- Residual Moisture (Karl Fischer Titration)
- ≤ 2.0% water content.
- Endotoxin Screening (LAL Assay)
- < 1.0 EU/mg (Limulus Amebocyte Lysate per USP <85>).
- Sterility Validation
- USP <71> compliant (no observed microbial proliferation in fluid thioglycollate or soybean-casein digest broths).
- Physical Characterization
- Dense, white to off-white lyophilized solid cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Highly hydrophilic; freely soluble in sterile laboratory-grade deionized water (≥ 25 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 20 mg/mL) for in vitro assay application.
- Proline-Rich Terminal Stability: The C-terminal -Pro-Gly-Pro motif provides steric protection against exopeptidase and carboxypeptidase hydrolysis; prepare working solutions freshly or store single-use aliquots at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Structural Origin & Classification: Synthetic regulatory heptapeptide engineered at the Institute of Molecular Genetics of the Russian Academy of Sciences. Structurally derived by extending the C-terminus of the endogenous immunomodulatory tetrapeptide Tuftsin (Thr-Lys-Pro-Arg) with a bio-stabilizing tripeptide sequence (Pro-Gly-Pro).
Cellular Pathways Investigated: Evaluated across in vitro neural and neuroendocrine cell cultures (including primary hippocampal neurons, cortical slices, and glial cultures) to analyze:
References (3)
- Semenova, T. P., et al. (2010). Effects of heptapeptide Selank on cognitive functions and monoaminergic systems in brain cell models. Bulletin of Experimental Biology and Medicine, 149(4), 434–437.
- Uchitel, I. A., et al. (2008). The effect of Selank on the enkephalin-degrading enzymes in in vitro systems. Rossiiskii Fiziologicheskii Zhurnal Imeni I. M. Sechenova, 94(4), 448–454.
- Kozlovskaya, M. M., et al. (2003). Anxiolytic and nootropic actions of Selank. Neuroscience and Behavioral Physiology, 33(9), 853–860.
Technical Laboratory FAQs
How does Selank relate structurally to endogenous Tuftsin?
Selank is an elongated analogue of Tuftsin (TKPR1--4) incorporating an additional C-terminal Pro-Gly-Pro sequence (PGP5--7), which increases resistance against rapid aminopeptidase cleavage while conferring allosteric neuromodulatory activity.
What biochemical cascades are triggered by Selank in neuronal culture models in vitro?
In cell-based models, Selank enhances GABA\text{A} receptor-mediated signaling, inhibits the enzymatic degradation of enkephalins, and stimulates the transcriptional synthesis of BDNF and its receptor TrkB.
What reconstitution vehicle is recommended for in vitro Selank assays?
Sterile deionized water or sterile PBS (pH 7.4) provides rapid dissolution at concentrations ≥ 20 mg/mL, creating an isotonic standard vehicle suitable for cell culture, enzymatic kinetics, and electrophysiological patch-clamp recordings.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.