Quantity
Price
$46.00
Out of stock
Ipamorelin
From $46.00to $660.00
For laboratory research use only. Not for human or animal use, consumption, diagnosis, treatment, or disease prevention.
This item is available only through approved account access.
Product Specifications
- Lot Number
- —
- Purity
- —
- Storage Temp
- 36°F to 46°F
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.
Documentation
Certificates of Analysis are supplied with each product lot where applicable.
Certificate of Analysis (COA)
Documentation will be available once product lots are received and tested.
All products currently listed on this site are for research purposes only.
COA Library
Published Certificates of Analysis for Ipamorelin. New deliveries are added as their batches are released.
No released COA for this strength yet
Reports appear here once a batch for this strength has been released.
Research Data
Chemical & Structural Identifiers
![2D chemical structure of (2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-phenylpropanoyl]amino]hexanamide](/structures/ipamorelin.svg)
- Chemical Name (IUPAC)
- (2S)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2S)-2-[(2-amino-2-methylpropanoyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
- CAS Registry Number
- 170851-70-4
- PubChem CID
- 9831659
- Molecular Formula
- C38H49N9O5
- Molecular Weight
- 711.39 Da (711.86 g/mol average)
- Sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH2 (Single-letter: Aib-H-[D-2Nal]-[D-Phe]-K-NH2)
- SMILES
- CC(C)(C(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC3=CC=CC=C3C=C2)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCCN)C(=O)N)N
- InChIKey
- LZKODFWWVBTBNG-UHFFFAOYSA-N
- Salt / Counter-Ion
- Supplied as a lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- Ipamorelin, NNC 26-0161, Aib-His-D-2-Nal-D-Phe-Lys-NH2
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (ESI-MS / MALDI-TOF)
- Theoretical mass [M+H]+ = 712.4 Da; observed mass-to-charge ratio m/z = 712.4 ± 0.4 Da.
- Residual Moisture (Karl Fischer Titration)
- ≤ 2.0% water content.
- Endotoxin Screening (LAL Assay)
- < 1.0 EU/mg (Limulus Amebocyte Lysate per USP <85>).
- Sterility Validation
- USP <71> compliant (no observed microbial proliferation in fluid thioglycollate/soybean-casein digest broths).
- Physical Characterization
- Dense, white to off-white lyophilized solid cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Freely soluble in sterile laboratory-grade deionized water (≥ 20 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 15 mg/mL) for in vitro assay application.
- Enzymatic Stability & Handling: Incorporates α-aminoisobutyric acid (Aib) and D-amino acid stereoisomers (D-2-Nal, D-Phe), conferring elevated resistance to standard aminopeptidases; prepare concentrated working stocks freshly or aliquot into single-use fractions at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Synthetic pentapeptide growth hormone secretagogue (GHS) that functions as a selective agonist of the Growth Hormone Secretagogue Receptor type 1a (GHS-R1a / ghrelin receptor).
Cellular Pathways Investigated: Evaluated in primary anterior pituitary cell cultures and somatotroph models to monitor Gαq/11-protein coupling, phospholipase C (PLC) activation, downstream inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) turnover, and intracellular calcium mobilization ([Ca2+]i). In comparative cell culture assays, Ipamorelin selectively stimulates growth hormone transcription without inducing non-specific transcription or release of adrenocorticotropic hormone (ACTH), cortisol, prolactin, or aldosterone.
References (3)
- Raun, K., et al. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552–561.
- Jimenez-Reina, L., et al. (2002). In vitro effects of the growth hormone secretagogue ipamorelin on anterior pituitary cells. Life Sciences, 71(15), 1735–1744.
- Bowers, C. Y. (2001). Synergistic release of growth hormone by GHRH and GHRP/ghrelin receptor agonists in pituitary cell cultures. Journal of Pediatric Endocrinology & Metabolism, 14(S2), 587–598.
Technical Laboratory FAQs
What structural features characterize Ipamorelin?
Ipamorelin is a synthetic pentapeptide containing an unnatural N-terminal α-aminoisobutyric acid (Aib1), D-stereoisomers (D-2-Nal3, D-Phe4), and a C-terminal amide cap (Lys5-NH2), which protect the peptide from rapid enzymatic degradation by dipeptidyl peptidases in laboratory assay media.
Why is Ipamorelin characterized as a selective GHS-R1a agonist in vitro?
Unlike first- and second-generation secretagogues (such as GHRP-2 or GHRP-6), Ipamorelin binds the GHS-R1a receptor with high selectivity, triggering growth hormone-related calcium influx without provoking secondary signaling cascades for prolactin, ACTH, or cortisol in pituitary cell models.
What solvent conditions are recommended for preparing in vitro Ipamorelin working stocks?
Sterile deionized water or sterile PBS (pH 7.4) dissolves the lyophilized powder rapidly at concentrations ≥ 15 mg/mL, creating an isotonic carrier solution suitable for biochemical receptor binding and cell-based assays.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.