IPA/CJC Blend
From $52.20to $435.00
Research blend of ipamorelin and CJC-1295, lyophilized reference standard for in vitro laboratory research.
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Price
$52.20
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Quantity
In Stock · 100 Units Available
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Certificate of Analysis & Specifications
Documentation will be published once this lot completes third-party analytical release.
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Published Certificates of Analysis for IPA/CJC Blend. All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
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Research Data
Chemical & Structural Identifiers
- Formulation
- Binary co-lyophilized peptide reference standard (dual GHRH receptor agonist + GHS-R1a secretagogue complex).
- Salt / Counter-Ion
- Supplied as a stoichiometric co-lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt mixture.
Constituent Peptides
Ipamorelin
Chemical Name: L-2-amino-2-methylpropanoyl-L-histidyl-3-(2-naphthyl)-D-alanyl-D-phenylalanyl-L-lysinamide · Primary Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2 · CAS Registry Number: 170851-70-4 · PubChem CID: 9831659 · Molecular Formula: C38H49N9O5 · Monoisotopic Molecular Weight: 711.39 Da (711.86 g/mol average) · SMILES Line Notation: CC(C)(C(=O)NC(CC1=CNC=N1)C(=O)NC(CC2=CC3=CC=CC=C3C=C2)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCCN)C(=O)N)N
CJC-1295 No DAC / Mod GRF 1-29
Chemical Name: [D-Ala2, Gln8, Ala15, Leu27]-GRF(1-29) amide · Primary Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 · CAS Registry Number: 863288-34-0 · PubChem CID: 56841944 · Molecular Formula: C152H252N44O42 · Monoisotopic Molecular Weight: 3365.89 Da (3367.95 g/mol average)
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- Individual peptide purities ≥ 98.5% (composite purity ≥ 98.0%) via baseline-resolved dual-peak gradient elution at λ = 214 nm and 220 nm.
- Ipamorelin identity
- Conforms to reference by retention time and UV spectrum.
- CJC-1295 (No DAC) identity
- Conforms to reference by retention time and UV spectrum.
- Physical Characterization
- Dense, white to off-white lyophilized solid cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Soluble in sterile laboratory-grade deionized water (≥ 15 mg/mL), sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 10 mg/mL), or dilute sterile 0.1% acetic acid for stock stabilization in in vitro assay applications.
- Handling & Solution Kinetics: Both components lack covalent bioconjugation linkers (non-DAC), exhibiting standard peptide half-life profiles in aqueous buffers; prepare working solutions freshly, avoid high-shear vortexing, and store single-use aliquots at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Dual-Pathway Synergy Model: Investigated in preclinical neuroendocrine and pituitary cell culture models to examine non-competitive, complementary growth hormone transcription signaling across distinct membrane receptors.
Ipamorelin Pathway (GHS-R1a Axis): Functions as a selective pentapeptide agonist of the Growth Hormone Secretagogue Receptor type 1a (ghrelin receptor). Upon binding, it couples to the Gαq/11 subunit, activating Phospholipase C (PLC), stimulating inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) turnover, and triggering rapid mobilization of intracellular calcium ([Ca2+]i) without activating the non-specific release of ACTH, cortisol, or prolactin in cell cultures.
CJC-1295 Pathway (GHRHR Axis): Functions as a 29-amino-acid analog of Growth Hormone-Releasing Hormone (GHRH1--29), selectively binding the GHRH receptor. Coupling to the Gαs subunit stimulates adenylyl cyclase, elevating intracellular cyclic AMP (cAMP) and activating Protein Kinase A (PKA) to promote gene transcription of growth hormone (GH1).
References (3)
- Raun, K., et al. (1998). Ipamorelin, the first selective growth hormone secretagogue. European Journal of Endocrinology, 139(5), 552–561.
- Campbell, R. M., et al. (1997). Selective amino acid substitutions enhance the in vitro enzymatic stability and potency of human growth hormone-releasing factor(1-29) analogues. Journal of Peptide Research, 49(6), 527–537.
- Bowers, C. Y. (2001). Synergistic release of growth hormone by GHRH and GHRP/ghrelin receptor agonists in pituitary cell cultures. Journal of Pediatric Endocrinology & Metabolism, 14(S2), 587–598.
Technical Laboratory FAQs
Why are Ipamorelin and CJC-1295 (No DAC) co-formulated in cell signaling research?
The blend allows researchers to model dual-receptor co-activation; Ipamorelin targets the Gαq-linked GHS-R1a receptor (calcium mobilization), while CJC-1295 activates the Gαs-linked GHRH receptor (cAMP pathway), demonstrating synergistic transcriptional kinetics in vitro.
How are both peptide components resolved and quantified in a single composite sample?
Reverse-phase HPLC (RP-HPLC) achieves baseline chromatographic separation between the smaller lipophilic pentapeptide Ipamorelin and the 29-residue tetrasubstituted CJC-1295, with each peak identified by retention time and UV spectral comparison against the reference standard.
What reconstitution vehicle is recommended for in vitro IPA/CJC assays?
Sterile deionized water or sterile PBS (pH 7.4) provides rapid dissolution for biological dilutions. For long-term stock stabilization against glutamine deamidation on the CJC-1295 peptide backbone, a dilute 0.1% sterile acetic acid solution is standard.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.