Quantity
Price
$28.00
100 available
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GHRP-6
From $28.00to $210.00
For laboratory research use only. Not for human or animal use, consumption, diagnosis, treatment, or disease prevention.
This item is available only through approved account access.
Product Specifications
- Lot Number
- —
- Purity
- —
- Storage Temp
- 36°F to 46°F
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.
Documentation
Certificates of Analysis are supplied with each product lot where applicable.
Certificate of Analysis (COA)
Documentation will be available once product lots are received and tested.
All products currently listed on this site are for research purposes only.
COA Library
Published Certificates of Analysis for GHRP-6. New deliveries are added as their batches are released.
No released COA for this strength yet
Reports appear here once a batch for this strength has been released.
Research Data
Chemical & Structural Identifiers
- Chemical Name (IUPAC)
- L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide
- CAS Registry Number
- 87616-84-0
- PubChem CID
- 9919153
- Molecular Formula
- C46H56N12O6
- Molecular Weight
- 872.44 Da (873.01 g/mol average)
- Sequence
- H-His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (Single-letter: H-[d-W]-A-W-[d-F]-K-NH2)
- SMILES
- C[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@H](CC3=CC=CC=C3)C(=O)N[C@@H](CCCCN)C(=O)N)NC(=O)[C@H](CC4=CNC5=CC=CC=C54)NC(=O)[C@@H](CC6=CNC=N6)N
- InChIKey
- VYPXZBSEUYGZOS-HBNGDCGZSA-N
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- GHRP-6, Growth Hormone Releasing Peptide-6, SKF-110679, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 280 nm (tryptophan indole chromophore detection).
- Identity Confirmation (ESI-MS / MALDI-TOF)
- Theoretical mass [M+H]+ = 873.5 Da; observed mass-to-charge ratio m/z = 873.5 ± 0.5 Da.
- Residual Moisture (Karl Fischer Titration)
- ≤ 2.0% water content.
- Endotoxin Screening (LAL Assay)
- < 1.0 EU/mg (Limulus Amebocyte Lysate per USP <85>).
- Sterility Validation
- USP <71> compliant (no observed microbial proliferation in liquid culture media).
- Physical Characterization
- Dense, white to off-white lyophilized solid cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct ambient light.
Solubility. Freely soluble in sterile laboratory-grade deionized water (≥ 20 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 15 mg/mL) for in vitro assay application.
- Photostability & Handling Parameters: Contains dual tryptophan residues (Trp2, Trp4) sensitive to photo-oxidation in aqueous environments; prepare concentrated working stocks under amber lighting conditions, avoid high-shear vortexing, and store single-use aliquots at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Synthetic first-generation hexapeptide growth hormone secretagogue (GHS) that functions as a selective agonist of the Growth Hormone Secretagogue Receptor type 1a (GHS-R1a / ghrelin receptor).
Cellular Pathways Investigated: Documented in in vitro anterior pituitary cell cultures and somatotroph assays to evaluate G-protein coupled (Gαq/11) signaling, activation of phospholipase C (PLC), generation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), mobilization of intracellular calcium ([Ca2+]i), and protein kinase C (PKC)-dependent stimulation of growth hormone transcription without displacing endogenous Growth Hormone-Releasing Hormone (GHRH).
References (3)
- Bowers, C. Y., et al. (1984). Structure-activity relationships of a synthetic pentapeptide that releases growth hormone in vitro. Endocrinology, 114(5), 1537–1545.
- Kojima, M., et al. (1999). Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature, 402(6762), 656–660.
- Camanni, F., et al. (1998). Growth hormone-releasing peptides and their analogs: Mechanisms of action in vitro and preclinical models. Frontiers in Neuroendocrinology, 19(1), 47–72.
Technical Laboratory FAQs
What structural features characterize GHRP-6?
GHRP-6 is a synthetic hexapeptide containing unnatural D-amino acid stereoisomers (D-Trp2 and D-Phe5) and a C-terminal amide cap (Lys6-NH2), which confer resistance against standard laboratory carboxypeptidases and endopeptidases.
How does GHRP-6 transduce signals in pituitary cell models in vitro?
GHRP-6 binds the GHS-R1a receptor, activating the PLC/IP3 pathway to stimulate transient intracellular calcium ([Ca2+]i) influx, distinct from the adenylyl cyclase/cAMP cascade activated by GHRH receptor agonists.
What solvent conditions are recommended for preparing in vitro GHRP-6 stock solutions?
Sterile deionized water or sterile PBS (pH 7.4) provides rapid dissolution at concentrations exceeding 15 mg/mL, establishing a neutral carrier solution for cell culture and biochemical modeling.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.