Cortagen
From $43.15to $359.62
Cortagen peptide, lyophilized reference standard for in vitro laboratory research.
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Price
$43.16
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Quantity
In Stock · 100 Units Available
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Certificate of Analysis & Specifications
Documentation will be published once this lot completes third-party analytical release.
Released COA Library
Published Certificates of Analysis for Cortagen. All released analytical records are preserved here. Pending and in-testing lots are reachable only through the QR printed on the vial.
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Research Data
Chemical & Structural Identifiers
![2D chemical structure of (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carboxylic acid (L-alanyl-L-$\alpha$-glutamyl-L-$\alpha$-aspartyl-L-proline)](/structures/cortagen.svg)
- Chemical Name (IUPAC)
- (2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]pyrrolidine-2-carboxylic acid (L-alanyl-L-α-glutamyl-L-α-aspartyl-L-proline)
- CAS Registry Number
- 332033-66-8
- PubChem CID
- 118984462
- Molecular Formula
- C17H26N4O9
- Molecular Weight
- 430.17 Da (430.41 g/mol average)
- Sequence
- H-Ala-Glu-Asp-Pro-OH (Single-letter: AEDP)
- SMILES
- C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)O)N
- InChIKey
- WNGVNDLODGVDJH-LREKUXGGSA-N
- Salt / Counter-Ion
- Supplied as a high-purity lyophilized acetate (CH3COO-) or trifluoroacetate (CF3COO-) salt.
- Synonyms
- Cortagen, AEDP Peptide, Ala-Glu-Asp-Pro, Cortex Bioregulator Analog
Analytical & COA Specifications
- Analytical Purity (RP-HPLC)
- ≥ 98.5% by area normalization under UV detection at λ = 214 nm and 220 nm.
- Identity Confirmation (RP-HPLC RT + UV vs. reference)
- Main peak retention time and UV spectrum conform to the reference standard.
- Physical Characterization
- Dense, white to off-white lyophilized solid cake/powder.
Handling & Stability
Storage. Store dry solid desiccated at -20°C to -80°C, protected from atmospheric moisture and direct light.
Solubility. Highly hydrophilic; freely soluble in sterile laboratory-grade deionized water (≥ 20 mg/mL) and sterile Phosphate-Buffered Saline (PBS, pH 7.4, ≥ 15 mg/mL) for in vitro assay preparation.
- Handling & Aliquoting: The C-terminal proline residue and contiguous carboxyl groups provide high structural stability against standard laboratory aminopeptidases; prepare concentrated working stocks freshly or store single-use aliquots at -20°C to eliminate degradation from repeated freeze-thaw cycles.
Mechanism & Literature
Structural Origin & Classification: Synthetic tetrapeptide (Ala-Glu-Asp-Pro) developed within the short-chain peptide bioregulator family as a targeted analogue of endogenous cerebral cortex polypeptide complexes.
Cellular Pathways Investigated: Documented in in vitro neural and glial cell cultures (including primary cortical neurons, PC12 pheochromocytoma cells, and astrocytes) to evaluate epigenetic regulation, direct sequence-specific peptide-DNA binding, upregulation of neurotrophic markers (such as NGF and BDNF mRNA transcripts), and modulation of the Bcl-2/Bax anti-apoptotic pathway under induced oxidative stress assay conditions.
References (3)
- Khavinson, V. K., et al. (2002). Effects of the synthetic tetrapeptide Cortagen on nerve cell differentiation and protein synthesis in vitro. Bulletin of Experimental Biology and Medicine, 134(4), 390–392.
- Sibilleva, N. N., et al. (2007). Interaction of short regulatory peptides with plant and animal chromatin in cell-free systems. Cell and Tissue Biology, 1(4), 312–318.
- Lezhava, T., et al. (2011). Bioregulatory peptide induction of chromatin deheterochromatinization in cultured human lymphocytes. Biogerontology, 12(4), 329–341.
Technical Laboratory FAQs
What is the sequence and structural classification of Cortagen?
Cortagen is a synthetic short-chain bioregulator tetrapeptide with the sequence Ala-Glu-Asp-Pro (AEDP), designed to model conserved sequence motifs found in cortical tissue fractions.
How does Cortagen (AEDP) differ structurally from Cartalax (AED)?
Cortagen incorporates an additional C-terminal L-proline residue (Pro4) to the Ala-Glu-Asp backbone, altering steric flexibility, increasing conformational rigidity, and modifying charge distribution during in vitro macromolecular binding assays.
What solvent conditions are recommended for in vitro Cortagen stock preparation?
Sterile deionized water or sterile PBS (pH 7.4) provides rapid dissolution at concentrations exceeding 15 mg/mL, creating an isotonic carrier standard for cell culture and biochemical modeling.
For Research Use Only. Not for human or animal administration. Not intended to diagnose, treat, cure, or prevent any disease. Sold for laboratory research purposes only.